Changes in the Hydrogen Ion Concentration of the Blood with Coagulation.*
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چکیده
Studies inquiring into the mechanism of blood clotting have been made by many careful investigators, and while much is written regarding the factors concerned, there is offered as yet no satisfactory and uniformly accepted explanation for t.he fact that blood usually clots when it escapes from a wound. Some of this confusion exists, perhaps, because the more recent investigations in colloidal chemistry were not available, and because some of the factors concerned with gel formation have not been understood. These last mentioned observations, especially, are significant since with them consideration has been taken of the importance of the H ion concentration of the gel medium, a factor whose relation to blood clotting has not been apparent and which to date seems to have received little attention. The work of Loeb (1) and others regarding the importance of the H ion concentration of the medium upon the behavior (ionization) of the proteins in solution and of the electrolytes as well, brings into studies of blood clotting this factor for consideration. Much of the work on blood clotting concerns the isolation of certain substances and the evaluation of their importance in the clotting mechanism. According to Bordet (2) coagulation of the blood is the aggregation into meshes of fibrin of particles of fibrinogen which Fredericq, 46 years ago, found in the plasma dispersed as a colloid. This substance, whether so named or otherwise, is accepted quite generally as the coagulating part of t.he blood clot. Another important const.ituent of the fibrin clot is calcium. Many years ago, Brticke (3) dcmonstratcd that fibrin left an ash containing calcium phosphate. Pekelharing and Hammarsten (4)
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تاریخ انتشار 2003